Description
The Genetic Counseling Shared Resource (GCSR) supports Cancer Center researchers studying the genetic basis of cancer. The GCSR currently
assists with studies to further define the phenotypes of hereditary cancer syndromes, identify new high- and low-penetrant cancer predisposition genes,
evaluate the psychosocial implications of genetic diagnoses, and evaluate screening and management approaches for high-risk patients.
The GCSR provides research assistance with study design, grant proposals, risk stratification, and recruitment of high-risk subjects. Other assistance
includes ensuring ethical standards of protocols and consents, coordinating genetic testing, and presenting genetic information to study participants.
The GCSR can provide support to projects in which gene testing or counseling may not be the central focus. While hereditary cancer syndromes are rare,
these conditions can often be excellent models for studying pathways involved with sporadic cancers. The GCSR can assist with obtaining biospecimens from
affected individuals. The GCSR participates in national and international networks and can use these connections to help researchers optimize recruitment
opportunities and to facilitate collaborations.
Pharmacogenetics is a rapidly growing area, and understanding how a participant’s genetic makeup may affect response to treatment is an important
component of interpreting clinical trial results. The GCSR can help researchers determine if genetic variants have been found that affect the metabolism of
the drug being studied and identify options for genetic testing. The GCSR can help incorporate this information into study design and the interpretation of
findings.
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